Weight loss injections have become a major breakthrough in recent years—offering real, medically backed results for people struggling to shed excess weight. Two of the biggest names on the scene are Wegovy and Mounjaro, both designed to reduce appetite, improve blood sugar control, and support long-term weight loss. But when it comes to Wegovy vs Mounjaro, which one works better?
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At Manchester Weight Loss Clinic, we help patients find the most suitable and effective option based on their goals, health history, and lifestyle.
In this guide, we’ll break down how they work, the differences between them, and what you should consider when choosing the right treatment for you.
What Are Wegovy and Mounjaro?
Let’s start with the basics.
Wegovy (Semaglutide)
Wegovy is a once-weekly injectable medication that mimics a hormone called GLP-1. This hormone helps to regulate appetite and food intake, making you feel fuller for longer and reducing cravings.
Wegovy is licensed for weight loss in the UK and is typically prescribed to people with a BMI of 30 or more, or 27+ if there are weight-related health conditions.
Mounjaro (Tirzepatide)
Mounjaro is a newer treatment that mimics two hormones: GLP-1 and GIP. It works similarly to Wegovy but targets both hormone pathways, potentially offering stronger appetite control and better blood sugar regulation.
Originally developed for type 2 diabetes, Mounjaro is now widely used off-label in the UK for weight management—and the results are impressive.
How Do They Compare for Weight Loss?
The big question: Wegovy vs Mounjaro—who comes out on top?
Effectiveness
Wegovy has shown average weight loss of around 15% of body weight over 68 weeks.
Mounjaro has gone even further, with some studies reporting up to 20% weight loss over a similar timeframe.
While individual results vary, early evidence suggests Mounjaro may be more effective for a larger percentage of users, particularly those with insulin resistance or type 2 diabetes.
Dosing Schedule
Both are once-weekly injections using pre-filled pens. However:
Wegovy has a fixed dose escalation schedule up to 2.4 mg
Mounjaro increases gradually and can go up to 15 mg, giving more flexibility based on your response
Side Effects
Both treatments can cause similar side effects, especially in the early weeks:
- Nausea
- Vomiting
- Constipation or diarrhoea
- Fatigue
- Reduced appetite
Mounjaro may cause slightly more digestive upset initially due to its dual-action mechanism, but most users adjust within a few weeks.
Who Might Prefer Wegovy?
Wegovy is ideal for people who:
- Prefer a licensed weight loss treatment with clear NHS or private access
- Have no history of type 2 diabetes
- Want a straightforward, single-hormone-based treatment
It’s also widely prescribed in the UK, making it easier to access through private clinics and pharmacies.
Who Might Prefer Mounjaro?
Mounjaro could be better for those who:
- Have insulin resistance or type 2 diabetes
- Have tried Wegovy and not seen the results they hoped for
- Need stronger appetite suppression
- Want a newer but potentially more effective option
It’s worth noting that while Mounjaro is not yet licensed specifically for weight loss in the UK, it’s used under private prescription and gaining traction due to its strong trial data.
Can You Switch Between Them?
Yes, with medical guidance. Some patients start with Wegovy and later transition to Mounjaro if weight loss stalls or side effects are an issue. However, switching isn’t a casual decision—you’ll need a proper review with your provider to ensure safety and suitability.
At Manchester Weight Loss Clinic, we support patients through this process and help assess when switching makes sense.
How to Choose the Right One
Still stuck on Wegovy vs Mounjaro? Here’s a simple breakdown:
Wegovy works by targeting a single hormone (GLP-1) and typically leads to around 15% weight loss on average. It’s available on the NHS and is a solid choice for simpler cases or those looking for steady, manageable progress. Side effects tend to be mild to moderate.
Mounjaro, on the other hand, targets both GLP-1 and GIP, which may result in greater weight loss—up to 20% in some cases. It’s not currently available on the NHS, but is offered privately and tends to suit tougher cases, including those with type 2 diabetes or insulin resistance. Side effects can be slightly stronger, especially during the early stages.
Want Help Choosing Between Wegovy and Mounjaro?
If you're comparing Wegovy vs Mounjaro, you're already taking a smart step toward understanding your weight loss options. Both treatments offer real results—but choosing the right one depends on your health background, goals, and how your body responds.
Contact us at Manchester Weight Loss Clinic today. We'll guide you through every stage of your treatment. From your first consultation to weekly or monthly support, we’ll help you choose the most effective injection for your needs.
This blog was written on behalf of Manchester Weight Loss Clinic by Pharmacy Mentor.