Ozempic has become a well-known name in the world of medical weight loss—but it’s not the only option available. Whether you've experienced side effects, can’t access it easily, or simply want to explore other treatments, there are several Ozempic alternatives worth considering.
Each medication works slightly differently and suits different types of patients. In this post, we’ll explore the most common alternatives, how they compare, and how to find the best fit for your weight loss journey.
At Manchester Weight Loss Clinic, we guide patients through safe, effective weight loss plans using clinically approved medications—whether that includes Ozempic or one of its alternatives.
Why People Are Looking for Alternatives to Ozempic
Ozempic (semaglutide) is a GLP-1 receptor agonist originally designed for managing type 2 diabetes. It also suppresses appetite and slows digestion, which is why it’s been used off-label to support weight loss.
However, it’s not suitable for everyone. Some reasons people seek alternatives include:
- Availability issues due to high demand
- Side effects like nausea, fatigue, or stomach upset
- No diabetes diagnosis, which limits NHS access
- Wanting licensed weight loss options specifically designed for weight management
Fortunately, there are several medications that offer similar or even enhanced effects.
1. Wegovy (Semaglutide)
Wegovy is made by the same manufacturer as Ozempic and contains the same active ingredient—semaglutide—but it’s licensed in the UK specifically for weight loss.
- How it works: Same as Ozempic (GLP-1 receptor agonist)
- Dose: Slightly higher than Ozempic, taken weekly
- Weight loss: Up to 15% of body weight on average
- Good for: People without type 2 diabetes seeking medically supervised weight loss
A popular option, Wegovy is one of the most straightforward alternatives if you're looking to stay with semaglutide but want a product tailored for weight loss.
2. Saxenda (Liraglutide)
Saxenda is another GLP-1 receptor agonist, but it requires a daily injection instead of weekly. It’s been available in the UK for several years and is licensed specifically for weight management.
- How it works: Similar to Ozempic but shorter acting
- Dose: Daily self-injection with a gradual increase
- Weight loss: Around 5–10% on average
- Good for: People who prefer a medication with longer safety history and NHS availability
While not quite as potent as Wegovy or Mounjaro, Saxenda can still offer steady results—especially when paired with lifestyle support.
3. Mounjaro (Tirzepatide)
Mounjaro is a newer treatment that goes one step further than Ozempic by targeting two hormones—GLP-1 and GIP. This dual action may result in stronger appetite control and enhanced weight loss.
- How it works: Mimics GLP-1 and GIP for better blood sugar and hunger regulation
- Dose: Weekly injection with flexible titration
- Weight loss: Up to 20% in some clinical trials
- Good for: People with insulin resistance, PCOS, or those who haven’t responded well to other treatments
Though not yet licensed specifically for weight loss in the UK, Mounjaro is available through private clinics and is gaining popularity fast.
4. Orlistat (Alli / Xenical)
Unlike the others on this list, Orlistat works in the digestive tract rather than affecting appetite. It blocks the absorption of some of the fat from your meals.
- How it works: Prevents fat absorption in the gut
- Dose: Taken as a capsule with meals
- Weight loss: Modest, around 5% with consistent use
- Good for: People who can’t take GLP-1 medications or prefer a non-hormonal option
Orlistat is available on prescription and over-the-counter, but side effects like digestive discomfort can be a drawback.
Choosing the Right Alternative
So which Ozempic alternative is best? That depends on:
- Your medical history and BMI
- Whether you have diabetes or insulin resistance
- How you prefer to take medication (daily vs weekly)
- Your experience with side effects or past treatments
- Whether you’re looking for an NHS or private option
At Manchester Weight Loss Clinic, we assess your needs carefully and recommend the treatment that suits you, not just what’s trending.
Want to Explore Ozempic Alternatives?
If you're looking for Ozempic alternatives, it’s important to understand your options and get expert advice tailored to your health. While Ozempic may work well for many, it’s not the only effective route to weight loss.
At Manchester Weight Loss Clinic, we offer personalised plans using safe, clinically backed treatments like Wegovy, Mounjaro, and Saxenda. Our friendly team can you take you through each of these options, explaining their pros and cons. Ultimately, we'll find you a weight loss treatment that works for your needs.
Get in touch and our team will guide you from your first consultation through to ongoing support—so you can feel confident every step of the way.
This blog was written on behalf of Manchester Weight Loss Clinic by Pharmacy Mentor.