Mounjaro (tirzepatide) is quickly becoming one of the most talked-about weight loss injections—and with good reason. Clinical trials show it can lead to an average weight reduction of up to 20%, making it one of the most effective options currently available. But if you're considering starting this treatment, one of the first questions you'll likely have is: what’s the right Mounjaro dose for weight loss?
At Manchester Weight Loss Clinic, we help patients across the UK safely use Mounjaro as part of a medically guided treatment plan. In this guide, we’ll walk you through how Mounjaro dosing works, how to know if it’s right for you, and what to expect from the process.
How Does Mounjaro Help with Weight Loss?
Before we get into dosing, it helps to understand how Mounjaro works. Tirzepatide, the active ingredient in Mounjaro, targets two key hormones: GLP-1 and GIP. These hormones help regulate blood sugar, slow digestion, and increase feelings of fullness—all of which help reduce your appetite and caloric intake.
Because it affects more than one pathway, Mounjaro can be more powerful than single-action alternatives like Saxenda or even Wegovy. But with greater potency comes the need for careful dose management.
Starting Doses: Why Low and Slow Matters
When beginning Mounjaro, you don’t jump straight to the highest dose. Like other weight loss injections, the treatment starts low and gradually increases. This gradual increase allows your body to adjust and helps minimise side effects such as nausea, bloating, or fatigue.
The starting dose is typically 2.5 mg once per week. This is considered a “non-therapeutic” dose, meaning it won’t cause major weight loss but is essential for helping your body get used to the medication.
After around four weeks, if well tolerated, you’ll likely move up to a 5 mg weekly dose—the first therapeutic level where weight loss effects begin to become more noticeable.
When Do the Higher Doses Come Into Play?
If you're responding well at 5 mg, your healthcare provider may suggest increasing the dose gradually—usually every 4 weeks—to optimise results. The next steps in the dosing ladder are:
- 7.5 mg
- 10 mg
- 12.5 mg
- 15 mg (the highest dose)
Not everyone will need or tolerate the maximum dose. In fact, some patients achieve excellent results on 7.5 or 10 mg and choose to stay there. The goal isn’t just to “go higher” but to find a dose that balances effectiveness with tolerability.
How Long Does It Take to See Results?
You might begin to notice appetite suppression and gradual weight loss during the 5 mg stage, especially when paired with dietary changes and regular activity. More significant weight loss tends to appear after reaching 10 mg or above, but results vary from person to person.
It's important to be consistent. Skipping doses or switching doses too quickly can reduce effectiveness or increase the risk of side effects. We always recommend sticking closely to your prescribed plan and checking in regularly with your clinician.
What Dose Is Right for Me?
The best dose for you depends on a few factors:
- Your current weight and BMI
- Your response to lower doses
- Your ability to manage side effects
- Other health conditions (e.g. diabetes, PCOS)
At Manchester Weight Loss Clinic, we tailor each plan based on your progress and preferences. Some patients prefer a slower titration to minimise side effects, while others are keen to progress more quickly if their body tolerates it well. There’s no one-size-fits-all approach—it’s about what works best for you.
Can I Adjust the Dose Myself?
No, you should never increase your Mounjaro dose without guidance from a medical professional. Jumping to a higher dose too quickly could lead to unpleasant side effects and make the treatment harder to stick with long-term.
Our team will work with you to assess how you're responding, adjust your plan as needed, and support you throughout your weight loss journey. Whether you’re moving from 5 mg to 7.5 mg or holding steady for a few extra weeks, every step is taken with your safety and comfort in mind.
Final Thoughts on Mounjaro Dosage
If you're looking for long-term, sustainable weight loss, Mounjaro offers a powerful and flexible treatment option—but only when used correctly. Finding the right dose isn’t about getting results overnight—it’s about choosing a level that works for your body, lifestyle, and goals.
Whether you’re just starting out or are ready to move up the dose ladder, we're here to guide you every step of the way.
Ready to Get Started with Mounjaro?
Wondering what the right Mounjaro dose for weight loss is for you? At Manchester Weight Loss Clinic, we offer full medical guidance, one-to-one support, and convenient at-home delivery of your prescription. You don’t have to navigate it alone—contact us today we’ll help you every step of the way.
This blog was written on behalf of Manchester Weight Loss Clinic by Pharmacy Mentor.