If you’ve recently started using Mounjaro, or are considering it as part of your weight loss journey, it’s natural to wonder what kind of progress you can expect and how soon you'll see results. Unlike fad diets or quick fixes, medically supervised weight loss with Mounjaro takes a gradual, sustainable approach. In this guide, we’ll explore what Mounjaro weight loss by week can realistically look like, and how Manchester Weight Loss Clinic supports you every step of the way.
What Is Mounjaro?
Mounjaro (tirzepatide) is a once-weekly injectable medication originally developed for type 2 diabetes, but it’s gained attention for its remarkable impact on weight loss. It works by mimicking two hormones, GLP-1 and GIP, that regulate appetite, blood sugar, and digestion. As a result, it helps reduce hunger, control cravings, and improve feelings of fullness after eating.
At Manchester Weight Loss Clinic, Mounjaro is offered as part of a tailored programme after a clinical consultation, ensuring you’re using the medication safely and effectively.
How Quickly Does Mounjaro Start Working?
Most people begin to notice changes in their appetite and eating habits within the first couple of weeks. Actual weight loss tends to follow soon after, especially when paired with healthy lifestyle changes.
It’s important to remember that results vary from person to person. Your starting weight, dosage, metabolism, and adherence to a tailored plan will all play a role.
Mounjaro Weight Loss Week by Week: A General Overview
Here’s a breakdown of what weight loss with Mounjaro may look like over time:
Week 1–2: Appetite Changes Begin
In the early weeks, most people notice a significant reduction in appetite. You may find yourself eating less, feeling full sooner, and having fewer cravings. Weight loss at this stage is usually modest, but the behavioural shift is a key early win.
Week 3–4: Early Weight Loss Appears
By the end of the first month, many users start to see the scales move. Typical weight loss is around 1–2 kg (2–4 lbs), but some may lose more, especially if starting from a higher BMI. You may also notice improvements in energy levels and mood.
Week 5–8: Momentum Builds
Weight loss generally becomes more noticeable during this period. At higher doses (e.g., 5mg or 7.5mg), some people report losing 4–6 kg (9–13 lbs) by week 8. Clothes may start to fit differently, and motivation can increase as progress becomes visible.
Week 9–12: Plateau or Progress?
Some users experience a temporary plateau as the body adjusts. This is a normal part of the journey. Your clinician may suggest a dose increase (up to 10mg or more depending on tolerance) or review your nutrition and activity levels. Regular check-ins with the clinic ensure your plan continues to align with your goals.
Week 13–16 and Beyond: Sustained Weight Loss
By three to four months in, many individuals experience sustained weight loss. For some, this can total 8–12 kg (18–26 lbs) or more, depending on dose and lifestyle. At this point, the benefits of Mounjaro often go beyond the scales, users may report reduced joint pain, improved sleep, and better blood pressure and cholesterol readings.
Weekly Progress vs Long-Term Goals
While it’s tempting to fixate on week-by-week numbers, it’s the overall trend and sustained habits that matter most. Healthy, steady weight loss tends to be more sustainable and less likely to result in rebound weight gain.
Mounjaro works best when combined with:
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Nutritionally balanced meals
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Regular physical activity (even gentle walking helps)
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Behavioural support or counselling, if needed
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Accountability through follow-ups
At Manchester Weight Loss Clinic, we tailor your plan to support both short-term wins and long-term lifestyle change.
How Much Does Mounjaro Cost?
At Manchester Weight Loss Clinic, Mounjaro is available in a range of doses, with prices starting from £129. As your treatment progresses, your prescriber may recommend increasing the dose to support your weight loss goals. This is subject to a clinical consultation. Here’s a full breakdown:
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Mounjaro 2.5mg – £129
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Mounjaro 5mg – £139
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Mounjaro 7.5mg – £159
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Mounjaro 10mg – £169
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Mounjaro 12.5mg – £179
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Mounjaro 15mg – £189
Prices include the medication and access to professional guidance from the clinic’s weight loss team. You’ll have ongoing check-ins to ensure the treatment is right for you at every stage.
Tracking Progress Without the Pressure
Not all progress is reflected on the scales. Here are other ways to measure your journey:
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Waist measurement changes
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Increased energy or stamina
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Improved sleep quality
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Fewer food cravings
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Better digestion or gut health
Your clinician can help you track both quantitative and qualitative progress, so you’re not relying on the scales alone.
Realistic Expectations with Mounjaro
Some users may lose 5% of their body weight within the first 12 weeks, while others may take longer — and that’s perfectly fine. Clinical trials have shown some individuals lose up to 15% or more of their starting body weight over several months.
The key is consistency. Mounjaro is not a quick fix, but a tool that works best as part of a bigger lifestyle shift, which is exactly what our programme is built around.
How Manchester Weight Loss Clinic Supports Your Journey
We offer:
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A detailed initial consultation
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Access to multiple doses of Mounjaro
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Regular follow-ups to adjust treatment
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Friendly, non-judgemental support
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Guidance around lifestyle, nutrition, and mindset
Whether you’re on week one or month five, we’re here to keep you on track and feeling confident.
Ready to Book Your Consultation?
If you’re curious about Mounjaro or want personalised advice on your weight loss journey, book a consultation at Manchester Weight Loss Clinic today. Your journey begins with expert guidance, and continues with steady, supported progress, week by week.
This blog was written on behalf of Manchester Weight Loss Clinic by Pharmacy Mentor.